Disease model | Modeling approach | Animal strains | Measurements |
Atherosclerosis rabbit model | abdominal aorta balloon injury | New Zealand white rabbit | Degree of atherosclerosis in the abdominal aorta |
Hyperlipidemia rat model | High fat diet | SD rat | Serum TC, TG, HDLC, LDLC and other blood lipid markers changes |
Spontaneous hypertensive rat model | Buy Spontaneous hypertensive rat strains | SHR rat | Whether the systolic pressure is higher than 120mmHg |
Immune myocarditis model | Subcutaneous injection of complete freund's adjuvant containing pig myocardial myosin | SD/Wistar rat BALB/c mouse | HE staining and Masson staining of heart tissue |
Pregnancy-induced hypertension syndrome(PIHS) model | intraperitoneal injection of DL-homocysteine from day 10 to day 19 of gestation | SD/Wistar female rat | Determination of systolic blood pressure |
Acute myocardial infarction(AMI) model | Ligate the left anterior descending coronary artery (LAD) | SD/Wistar rat C57BL/6 mouse | Measurement of Cardiac Function by Echocardiography; TTC staining with Evans blue perfusion; HE staining and Masson staining of heart tissue |
Chronic heart failure(CHF) model | Abdominal aorta coarctation | SD/Wistar rat | Observe fur color and respiratory rate; Heart tissue pathological analysis |
Rat model of arrhythmia | Intravenous injection of aconitine | SD/Wistar rat | ECG changes were recorded |
Rat model of septic shock | Injection of LPS | SD/Wistar rat | Visually inspect for shock symptoms |
Anaphylactic shock model | Injection of horse serum | SD/Wistar rat |
TOPBIOTECH can provide and develop animal models of various diseases according to customers' requirements |
Case analysis Atherosclerosis rabbit model
A rabbit model of atherosclerosis prepared by abdominal aortic balloon injury showed a lesion process similar to that of human atherosclerosis, which has been widely used in studies on the mechanism of atherosclerosis, drug screening and drug validation.
Experimental animal information |
Name of animal model | Atherosclerosis in rabbit model |
Species and strains of animal | New Zealand white rabbit |
Gender of animal | ♂ |
Age of animal | adult |
Weight of animal | 2~3.5kg |
Caracteristics
The body weight was significantly higher; severe fatty liver was seen; perirenal fat was thickened; fat was wrapped in the outer wall of abdominal aorta. After separation of abdominal aorta, the internal lipid plaquesins the abdominal aorta were visible to the naked eye, and the abdominal aorta was thickened and the elasticity was poor.
Partial surgical process display
