Source: in 1921, little obtained C57BL by mating with Abby Lathrop mouse strain, female 57 and male 52. In 1937, two sublines C57BL / 6 and C57BL / 10 were isolated from C57BL. In 1985, he was
introduced from OLAC to the Institute of experimental animals, Chinese Academy of Medical Sciences.

Coat color: black.

Main characteristics: ① the natural incidence of breast tumors is low, and chemicals are difficult to induce breast and ovarian tumors. ② 12% had eye defect; 16.8% of female offspring and 3% of male
offspring had small eyes or no eyes. Cleft palate can be induced by cortisone, and the incidence is 20%. ③ Moderate tolerance to radioactive substances; High complement activity; It is easy to induce
immune tolerance. ④ Sensitive to Mycobacterium tuberculosis. It has certain resistance to mouse pox virus. ⑤ Interferon production is high. ⑥ Alcoholism is high, and the concentration of adrenaline
lipids is low. It is sensitive to pertussis histamine susceptibility factors. ⑦ Inbred lines, often regarded as "standard", provide genetic background for many mutant genes.

Main uses: it is a strain commonly used in oncology, physiology, immunology and genetics.